Microarray analysis reveals previously unknown changes in Toxoplasma gondii-infected human cells
IJ Blader, ID Manger, JC Boothroyd - Journal of Biological Chemistry, 2001 - ASBMB
Cells infected with the intracellular protozoan parasite Toxoplasma gondii undergo up-
regulation of pro-inflammatory cytokines, organelle redistribution, and protection from
apoptosis. To examine the molecular basis of these and other changes, gene expression
profiles of human foreskin fibroblasts infected with Toxoplasma were studied using human
cDNA microarrays consisting of∼ 22,000 known genes and uncharacterized expressed
sequence tags. Early during infection (1–2 h),< 1% of all genes show a significant change in …
regulation of pro-inflammatory cytokines, organelle redistribution, and protection from
apoptosis. To examine the molecular basis of these and other changes, gene expression
profiles of human foreskin fibroblasts infected with Toxoplasma were studied using human
cDNA microarrays consisting of∼ 22,000 known genes and uncharacterized expressed
sequence tags. Early during infection (1–2 h),< 1% of all genes show a significant change in …
