MINI REVIEW Carbohydrate sulfotransferases in lymphocyte homing
S Hemmerich, SD Rosen - Glycobiology, 2000 - academic.oup.com
S Hemmerich, SD Rosen
Glycobiology, 2000•academic.oup.comSulfation is a critical modification in many instances of biological recognition. Early work in
lymphocyte homing indicated that the endothelial ligands for L-selectin depended upon
sulfation modifications. Subsequent studies showed that the two specific modifications, Gal-
6-SO4 and GlcNAc-6-SO4, were present on actual biological ligands. Recently, a family of
carbohydrate sulfotransferases capable of generating these modifications has been
identified at the molecular level. Reconstitution experiments implicate members of this family …
lymphocyte homing indicated that the endothelial ligands for L-selectin depended upon
sulfation modifications. Subsequent studies showed that the two specific modifications, Gal-
6-SO4 and GlcNAc-6-SO4, were present on actual biological ligands. Recently, a family of
carbohydrate sulfotransferases capable of generating these modifications has been
identified at the molecular level. Reconstitution experiments implicate members of this family …
Abstract
Sulfation is a critical modification in many instances of biological recognition. Early work in lymphocyte homing indicated that the endothelial ligands for L-selectin depended upon sulfation modifications. Subsequent studies showed that the two specific modifications, Gal-6-SO4 and GlcNAc-6-SO4, were present on actual biological ligands. Recently, a family of carbohydrate sulfotransferases capable of generating these modifications has been identified at the molecular level. Reconstitution experiments implicate members of this family as critical participants in lymphocyte homing.
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