Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling
Journal of bacteriology, 1996•Am Soc Microbiol
Acylated homoserine lactones (AHLs) play a widespread role in intercellular communication
among bacteria. The Australian macroalga Delisea pulchra produces secondary metabolites
which have structural similarities to AHL molecules. We report here that these metabolites
inhibited AHL-controlled processes in prokaryotes. Our results suggest that the interaction
between higher organisms and their surface-associated bacteria may be mediated by
interference with bacterial regulatory systems.
among bacteria. The Australian macroalga Delisea pulchra produces secondary metabolites
which have structural similarities to AHL molecules. We report here that these metabolites
inhibited AHL-controlled processes in prokaryotes. Our results suggest that the interaction
between higher organisms and their surface-associated bacteria may be mediated by
interference with bacterial regulatory systems.
Acylated homoserine lactones (AHLs) play a widespread role in intercellular communication among bacteria. The Australian macroalga Delisea pulchra produces secondary metabolites which have structural similarities to AHL molecules. We report here that these metabolites inhibited AHL-controlled processes in prokaryotes. Our results suggest that the interaction between higher organisms and their surface-associated bacteria may be mediated by interference with bacterial regulatory systems.
American Society for Microbiology