Ischemia impairs liver regeneration after major tissue loss in rodents: protective effects of interleukin-6
M Selzner, CA Camargo, PA Clavien - Hepatology, 1999 - journals.lww.com
The effects of ischemia on the regenerative capacity of the liver after major tissue loss
remain unclear. Interleukin-6 (IL-6) has been shown to confer protection in models of
normothermic ischemia and reperfusion injury and to initiate hepatocyte proliferation after
major hepatectomy. Therefore, we investigated the effects of ischemia on the regenerative
capacity of the liver and evaluated the role of IL-6 in reducing reperfusion injury and
enhancing hepatic proliferation in models combining ischemia and major hepatectomy. Rats …
remain unclear. Interleukin-6 (IL-6) has been shown to confer protection in models of
normothermic ischemia and reperfusion injury and to initiate hepatocyte proliferation after
major hepatectomy. Therefore, we investigated the effects of ischemia on the regenerative
capacity of the liver and evaluated the role of IL-6 in reducing reperfusion injury and
enhancing hepatic proliferation in models combining ischemia and major hepatectomy. Rats …
