Transforming growth factor-β: biological function and chemical structure
MB Sporn, AB Roberts, LM Wakefield, RK Assoian - Science, 1986 - science.org
MB Sporn, AB Roberts, LM Wakefield, RK Assoian
Science, 1986•science.orgTransforming growth factor-β (TGF-β) is a multifunctional peptide that controls proliferation,
differentiation, and other functions in many cell types. Many cells synthesize TGF-β and
essentially all of them have specific receptors for this peptide. TGF-β regulates the actions of
many other peptide growth factors and determines a positive or negative direction of their
effects. Its marked ability to enhance formation of connective tissue in vivo suggests several
therapeutic applications.
differentiation, and other functions in many cell types. Many cells synthesize TGF-β and
essentially all of them have specific receptors for this peptide. TGF-β regulates the actions of
many other peptide growth factors and determines a positive or negative direction of their
effects. Its marked ability to enhance formation of connective tissue in vivo suggests several
therapeutic applications.
Transforming growth factor-β (TGF-β) is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGF-β and essentially all of them have specific receptors for this peptide. TGF-β regulates the actions of many other peptide growth factors and determines a positive or negative direction of their effects. Its marked ability to enhance formation of connective tissue in vivo suggests several therapeutic applications.
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