Epidermal growth factor receptor family in lung cancer and premalignancy
WA Franklin, R Veve, FR Hirsch, BA Helfrich… - Seminars in …, 2002 - Elsevier
Lung cancer, like many other epithelial malignancies, is thought to be the outcome of
genetic and epigenetic changes that result in a constellation of phenotypic abnormalities in
bronchial epithelium. These include morphologic epithelial dysplasia, angiogenesis,
increased proliferative rate, and changes in expression of cell surface proteins, particularly
overexpression of epidermal growth factor receptor (EGFR) family proteins. The EFGR family
is a group of four structurally similar tyrosine kinases (EGFR, HER2/neu, ErbB-3, and ErbB …
genetic and epigenetic changes that result in a constellation of phenotypic abnormalities in
bronchial epithelium. These include morphologic epithelial dysplasia, angiogenesis,
increased proliferative rate, and changes in expression of cell surface proteins, particularly
overexpression of epidermal growth factor receptor (EGFR) family proteins. The EFGR family
is a group of four structurally similar tyrosine kinases (EGFR, HER2/neu, ErbB-3, and ErbB …