Comparative effect of isotretinoin and etretinate on acne and sebaceous gland secretion
JA Goldstein, A Socha-Szott, RJ Thomsen… - Journal of the American …, 1982 - Elsevier
Isotretinoin (13-cis-retinoic acid) was compared with the aromatic retinoid, etretinate, in
patients with severe nodulocystic acne. Evaluation of fifty-six such men receiving 1 mg/kg of
one or the other of these two drugs was performed with regard to clinical improvement and
change in sebum production. Lesion counting demonstrated a significant improvement in
patients receiving isotretinoin, particularly in facial lesions. There was significantly less
improvement with etretinate. Similarly, isotretinoin produced a marked suppression of …
patients with severe nodulocystic acne. Evaluation of fifty-six such men receiving 1 mg/kg of
one or the other of these two drugs was performed with regard to clinical improvement and
change in sebum production. Lesion counting demonstrated a significant improvement in
patients receiving isotretinoin, particularly in facial lesions. There was significantly less
improvement with etretinate. Similarly, isotretinoin produced a marked suppression of …
