Integrins mediate cell adhesion, permit traction forces important for cell migration, and cross‐
talk with growth factor receptors to regulate cell proliferation, cell survival, and cell
differentiation. The plethora of functions explains their central role for development and
disease. The progress in mouse genetics and the ease with which the mouse genome can
be manipulated enormously contributed to our understanding of how integrins exert their
functions at the molecular level. In the present chapter, we describe tests that are routinely …