The impact of gene profiling in chronic myeloid leukaemia
ASM Yong, JV Melo - Best practice & research Clinical haematology, 2009 - Elsevier
The use of microarray technology in chronic myeloid leukaemia (CML) has increased our
understanding of the biology of this disease. From early studies of gene expression profiling
in BCR-ABL-positive cell lines to samples from patients in different disease phases of CML,
using resting cells or cells treated with a variety of therapeutic agents, the field has now
moved on to profiling microRNA and single nucleotide polymorphisms of CML cells. With the
advent of tyrosine kinase inhibitors, several groups have also attempted to use microarray …
understanding of the biology of this disease. From early studies of gene expression profiling
in BCR-ABL-positive cell lines to samples from patients in different disease phases of CML,
using resting cells or cells treated with a variety of therapeutic agents, the field has now
moved on to profiling microRNA and single nucleotide polymorphisms of CML cells. With the
advent of tyrosine kinase inhibitors, several groups have also attempted to use microarray …