[HTML][HTML] Myogenic stage, sarcomere length, and protease activity modulate localization of muscle-specific calpain
K Ojima, Y Ono, N Doi, K Yoshioka, Y Kawabata… - Journal of biological …, 2007 - ASBMB
p94/calpain 3 is a Ca 2+-binding intracellular protease predominantly expressed in skeletal
muscles. p94 binds to the N2A and M-line regions of connectin/titin and localizes in the Z-
bands. Genetic evidence showing that compromised p94 proteolytic activity leads to
muscular dystrophy (limb-girdle muscular dystrophy type 2A) indicates the importance of
p94 function in myofibrils. Here we show that a series of p94 splice variants is expressed
immediately after muscle differentiation and differentially change localization during …
muscles. p94 binds to the N2A and M-line regions of connectin/titin and localizes in the Z-
bands. Genetic evidence showing that compromised p94 proteolytic activity leads to
muscular dystrophy (limb-girdle muscular dystrophy type 2A) indicates the importance of
p94 function in myofibrils. Here we show that a series of p94 splice variants is expressed
immediately after muscle differentiation and differentially change localization during …
