The role of inflammation in early and late venous thrombosis: Are there clinical implications?
TW Wakefield, PK Henke - Seminars in vascular surgery, 2005 - Elsevier
Venous thrombosis is associated with a significant inflammatory response. Inflammatory
cells, adhesion molecules (especially selectins), cytokines, and procoagulant microparticles
appear to be associated with the thrombogenic process. Once thrombus forms, inflammatory
cells are important to thrombus resolution along with fibrinolytic agents and proinflammatory
mediators. Collagen and elastin breakdown by the DVT renders the vein wall stiff and non-
compliant. Rapid and complete thrombus resolution should lessen vein wall damage and …
cells, adhesion molecules (especially selectins), cytokines, and procoagulant microparticles
appear to be associated with the thrombogenic process. Once thrombus forms, inflammatory
cells are important to thrombus resolution along with fibrinolytic agents and proinflammatory
mediators. Collagen and elastin breakdown by the DVT renders the vein wall stiff and non-
compliant. Rapid and complete thrombus resolution should lessen vein wall damage and …