[HTML][HTML] Species-specific regulation of Toll-like receptor 3 genes in men and mice
S Heinz, V Haehnel, M Karaghiosoff… - Journal of Biological …, 2003 - ASBMB
Toll-like receptor 3 (TLR3) belongs to a family of evolutionary conserved innate immune
recognition molecules and recognizes double-stranded RNA, a molecular pattern
associated with viral infections. Earlier studies suggested a differential expression pattern in
men and mice; the molecular basis for this observation, however, was unknown. Here we
demonstrate that species-specific differences in tissue expression and responses to
lipopolysaccaride (LPS) coincide with the presence of different, evolutionary non-conserved …
recognition molecules and recognizes double-stranded RNA, a molecular pattern
associated with viral infections. Earlier studies suggested a differential expression pattern in
men and mice; the molecular basis for this observation, however, was unknown. Here we
demonstrate that species-specific differences in tissue expression and responses to
lipopolysaccaride (LPS) coincide with the presence of different, evolutionary non-conserved …