[HTML][HTML] Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling
K Kasuno, S Takabuchi, K Fukuda… - Journal of Biological …, 2004 - ASBMB
Hypoxia-inducible factor-1 (HIF-1) is a master regulator of cellular adaptive responses to
hypoxia. Levels of the HIF-1α subunit increase under hypoxic conditions. Exposure of cells
to certain nitric oxide (NO) donors also induces HIF-1α expression under nonhypoxic
conditions. We demonstrate that exposure of cells to the NO donor NOC18 or S-
nitrosoglutathione induces HIF-1α expression and transcriptional activity. In contrast to
hypoxia, NOC18 did not inhibit HIF-1α hydroxylation, ubiquitination, and degradation …
hypoxia. Levels of the HIF-1α subunit increase under hypoxic conditions. Exposure of cells
to certain nitric oxide (NO) donors also induces HIF-1α expression under nonhypoxic
conditions. We demonstrate that exposure of cells to the NO donor NOC18 or S-
nitrosoglutathione induces HIF-1α expression and transcriptional activity. In contrast to
hypoxia, NOC18 did not inhibit HIF-1α hydroxylation, ubiquitination, and degradation …