[HTML][HTML] Herpesvirus entry mediator ligand (HVEM-L), a novel ligand for HVEM/TR2, stimulates proliferation of T cells and inhibits HT29 cell growth
JA Harrop, PC McDonnell, M Brigham-Burke… - Journal of Biological …, 1998 - ASBMB
Herpesvirus entry mediator (HVEM), a member of the tumor necrosis factor (TNF) receptor
family, mediates herpesvirus entry into cells during infection. Upon overexpression, HVEM
activates NF-κB and AP-1 through a TNF receptor-associated factor (TRAF)-mediated
mechanism. Using an HVEM-Fc fusion protein, we screened soluble forms of novel TNF-
related proteins derived from an expressed sequence tag data base. One of these, which we
designated HVEM-L, specifically bound to HVEM-Fc with an affinity of 44 nm. This …
family, mediates herpesvirus entry into cells during infection. Upon overexpression, HVEM
activates NF-κB and AP-1 through a TNF receptor-associated factor (TRAF)-mediated
mechanism. Using an HVEM-Fc fusion protein, we screened soluble forms of novel TNF-
related proteins derived from an expressed sequence tag data base. One of these, which we
designated HVEM-L, specifically bound to HVEM-Fc with an affinity of 44 nm. This …