Thalassemia intermedia: revisited
A Taher, H Isma'eel, MD Cappellini - Blood Cells, Molecules, and Diseases, 2006 - Elsevier
Thalassemia intermedia encompasses a wide clinical spectrum of beta-thalassemia
phenotypes. Some thalassemia intermedia patients are asymptomatic until adult life,
whereas others are symptomatic from as young as 2 years of age. A number of clinical
complications commonly associated with thalassemia intermedia are rarely seen in
thalassemia major, including extramedullary hematopoiesis, leg ulcers, gallstones and
thrombophilia. Prevention of these complications, possibly with blood transfusion therapy, is …
phenotypes. Some thalassemia intermedia patients are asymptomatic until adult life,
whereas others are symptomatic from as young as 2 years of age. A number of clinical
complications commonly associated with thalassemia intermedia are rarely seen in
thalassemia major, including extramedullary hematopoiesis, leg ulcers, gallstones and
thrombophilia. Prevention of these complications, possibly with blood transfusion therapy, is …