H-ras oncogene mutation and human papillomavirus infection in oral carcinomas
JA Anderson, JC Irish, CM McLachlin… - … –Head & Neck Surgery, 1994 - jamanetwork.com
Objective: Previous in vitro studies have demonstrated that transfection of an
activatedrasgene induces malignant transformation in epithelial cell lines infected with the
human papillomavirus (HPV). The results of these studies support the hypothesis that HPV
may co-operate with an activatedrasgene in epithelial tumor carcinogenesis. To test this
hypothesis in head and neck cancers, we screened 35 oral carcinomas for the presence of
HPV DNA and for a mutated H-ras gene. Design: The design of the study was a screening …
activatedrasgene induces malignant transformation in epithelial cell lines infected with the
human papillomavirus (HPV). The results of these studies support the hypothesis that HPV
may co-operate with an activatedrasgene in epithelial tumor carcinogenesis. To test this
hypothesis in head and neck cancers, we screened 35 oral carcinomas for the presence of
HPV DNA and for a mutated H-ras gene. Design: The design of the study was a screening …
