Modulation of growth factor and cytokine expression by nitric oxide during rat colon anastomotic healing
DT Efron, D Most, HP Shi, US Tantry… - Journal of gastrointestinal …, 2003 - Elsevier
We have previously shown that inhibition of nitric oxide generated by inducible nitric oxide
synthase (iNOS) results in impaired colon anastomotic healing. Therefore, we proceeded to
assess whether disruption of iNOS activity alters the normal pattern of growth factor
expression during anastomotic healing. Two groups of male Sprague-Dawley rats
underwent distal colonic division and anastomosis, jugular venous catheterization and
subcutaneous placement of polyvinyl alcohol sponges. The first group (n= 10) received q8 …
synthase (iNOS) results in impaired colon anastomotic healing. Therefore, we proceeded to
assess whether disruption of iNOS activity alters the normal pattern of growth factor
expression during anastomotic healing. Two groups of male Sprague-Dawley rats
underwent distal colonic division and anastomosis, jugular venous catheterization and
subcutaneous placement of polyvinyl alcohol sponges. The first group (n= 10) received q8 …