Emerging paradigms of T-cell co-stimulation
RA Kroczek, HW Mages, A Hutloff - Current opinion in immunology, 2004 - Elsevier
RA Kroczek, HW Mages, A Hutloff
Current opinion in immunology, 2004•ElsevierThe analysis of recent data reveals that T-cell co-stimulation is a hierarchical process with
elements of mutual interdependence between individual co-stimulators. The expression and
function of co-stimulatory molecules is biased on various T-cell subsets and is dependent on
the T-cell differentiation state. The classical paradigm of T-cell co-stimulation by professional
antigen-presenting cells has to incorporate the newly recognized concept of T-cell co-
stimulation in the interaction with peripheral tissues, such as endothelial or epithelial cells …
elements of mutual interdependence between individual co-stimulators. The expression and
function of co-stimulatory molecules is biased on various T-cell subsets and is dependent on
the T-cell differentiation state. The classical paradigm of T-cell co-stimulation by professional
antigen-presenting cells has to incorporate the newly recognized concept of T-cell co-
stimulation in the interaction with peripheral tissues, such as endothelial or epithelial cells …
The analysis of recent data reveals that T-cell co-stimulation is a hierarchical process with elements of mutual interdependence between individual co-stimulators. The expression and function of co-stimulatory molecules is biased on various T-cell subsets and is dependent on the T-cell differentiation state. The classical paradigm of T-cell co-stimulation by professional antigen-presenting cells has to incorporate the newly recognized concept of T-cell co-stimulation in the interaction with peripheral tissues, such as endothelial or epithelial cells. The two signal paradigm of T-cell co-stimulation is being replaced by a multisignal integration concept of central and peripheral co-stimulation.
Elsevier