B cell–derived exosomes can present allergen peptides and activate allergen-specific T cells to proliferate and produce TH2-like cytokines
C Admyre, B Bohle, SM Johansson… - Journal of Allergy and …, 2007 - Elsevier
BACKGROUND: Exosomes are vesicles of 30 to 100 nm produced by inward budding of
endosomal compartments and are released by a range of different cell types. Exosomes
from antigen-presenting cells carry immunorelevant molecules like MHC class I and II and
costimulatory molecules and thus are suggested to have a role in immune modulation.
OBJECTIVE: To investigate the role of antigen-presenting cell derived exosomes in allergen
presentation and T-cell stimulation. METHODS: Exosomes were isolated from supernatants …
endosomal compartments and are released by a range of different cell types. Exosomes
from antigen-presenting cells carry immunorelevant molecules like MHC class I and II and
costimulatory molecules and thus are suggested to have a role in immune modulation.
OBJECTIVE: To investigate the role of antigen-presenting cell derived exosomes in allergen
presentation and T-cell stimulation. METHODS: Exosomes were isolated from supernatants …