Interplay between mTOR and STAT5 signaling modulates the balance between regulatory and effective T cells
Background Immune response outcome, inflammation or tolerance, often depends on the
balance between regulatory T cells (Tregs) and effective T cells (Teffs). Rapamycin (Rapa)
has been reported to selectively expand Tregs and promote de novo generation of foxp3+
Tregs, suggesting its potential role in inducing tolerance. But the mechanism by which Rapa
regulating the Treg–Teff balance is yet to be understood. Methods Mouse CD4+ CD25−
Teffs and CD4+ CD25+ Tregs are sorted by MACS. These T cell subsets were labeled with …
balance between regulatory T cells (Tregs) and effective T cells (Teffs). Rapamycin (Rapa)
has been reported to selectively expand Tregs and promote de novo generation of foxp3+
Tregs, suggesting its potential role in inducing tolerance. But the mechanism by which Rapa
regulating the Treg–Teff balance is yet to be understood. Methods Mouse CD4+ CD25−
Teffs and CD4+ CD25+ Tregs are sorted by MACS. These T cell subsets were labeled with …