Highlights•Hypoxia is a prominent feature in inflamed tissues.•The HIF pathway is a potential
therapeutic target in inflammation.•Hydroxylase inhibition is anti-inflammatory in models of
inflammation.Oxygen deprivation (hypoxia) is a frequently encountered condition in both
health and disease. Metazoans have evolved an elegant and direct cellular mechanism by
which to sense local oxygen levels and mount an adaptive transcriptional response to
hypoxia which is mediated by a transcription factor termed the hypoxia-inducible factor (HIF) …