Hypoxia-inducible factor-2α limits natural killer T cell cytotoxicity in renal ischemia/reperfusion injury
J Zhang, C Han, H Dai, J Hou, Y Dong… - Journal of the …, 2016 - journals.lww.com
Natural killer T (NKT) cells are the major early-acting immune cell type and fundamental
immune modulators in ischemia-reperfusion injury (IRI). Because lymphocytes are exposed
to various oxygen tensions under pathophysiologic conditions, we hypothesize that hypoxia-
inducible factors (HIFs) have roles in NKT cell activation, and thus determine the final
outcome of renal IRI. In this study, we used Lck-Cre transgenic mice to specifically disrupt
HIF-2α in T/NKT cells and found that HIF-2α knockout led to upregulated Fas ligand …
immune modulators in ischemia-reperfusion injury (IRI). Because lymphocytes are exposed
to various oxygen tensions under pathophysiologic conditions, we hypothesize that hypoxia-
inducible factors (HIFs) have roles in NKT cell activation, and thus determine the final
outcome of renal IRI. In this study, we used Lck-Cre transgenic mice to specifically disrupt
HIF-2α in T/NKT cells and found that HIF-2α knockout led to upregulated Fas ligand …