Role of Erk1/2 activation in prion disease pathogenesis: absence of CCR1 leads to increased Erk1/2 activation and accelerated disease progression
RA LaCasse, JF Striebel, C Favara, L Kercher… - Journal of …, 2008 - Elsevier
Prion diseases are neurodegenerative infections with gliosis and vacuolation. The
mechanisms of degeneration remain unclear, but chemokines may be important. In current
experiments CCR1 knock-out (KO) mice succumbed more rapidly to scrapie infection than
WT controls. Infected KO mice had upregulation of CCL3, a CCR1 ligand, and CCR5, a
receptor with specificity for CCL3. Both infected KO and WT mice had upregulation of CCR5-
mediated signaling involving activation of Erk1/2 in astrocytes; however, activation was …
mechanisms of degeneration remain unclear, but chemokines may be important. In current
experiments CCR1 knock-out (KO) mice succumbed more rapidly to scrapie infection than
WT controls. Infected KO mice had upregulation of CCL3, a CCR1 ligand, and CCR5, a
receptor with specificity for CCL3. Both infected KO and WT mice had upregulation of CCR5-
mediated signaling involving activation of Erk1/2 in astrocytes; however, activation was …