TRIM5 allelic polymorphism in macaque species/populations of different geographic origins: its impact on SIV vaccine studies

NG de Groot, CMC Heijmans, G Koopman… - Tissue …, 2011 - Wiley Online Library
NG de Groot, CMC Heijmans, G Koopman, EJ Verschoor, WM Bogers, RE Bontrop
Tissue antigens, 2011Wiley Online Library
Tripartite motif 5α (TRIM5α) is a potent antiretroviral immune factor present in the cytoplasm
of cells of most tissue types. The rhesus macaque TRIM5 gene has been shown to display
polymorphism, with different variants being divided into three groups (TRIM5TFP, TRIM5Q,
and TRIM5CypA), which may have divergent retroviral effects on infection. Along with rhesus
macaques, cynomolgus macaques are also used in simian immunodeficiency virus (SIV)
infection studies. As a consequence, TRIM5 genotyping of these animals will contribute to …
Tripartite motif 5α (TRIM5α) is a potent antiretroviral immune factor present in the cytoplasm of cells of most tissue types. The rhesus macaque TRIM5 gene has been shown to display polymorphism, with different variants being divided into three groups (TRIM5TFP, TRIM5Q, and TRIM5CypA), which may have divergent retroviral effects on infection. Along with rhesus macaques, cynomolgus macaques are also used in simian immunodeficiency virus (SIV) infection studies. As a consequence, TRIM5 genotyping of these animals will contribute to interpreting the outcome of such studies. The present communication covers Burmese, Chinese, and a large cohort of Indian‐origin rhesus macaques, and describes the first large cohort study on TRIM5 polymorphism in outbred cynomolgus macaques. We demonstrate the presence of the TRIM5TFP group in cynomolgus macaques. In addition, we have re‐evaluated historical samples of rhesus macaques challenged with SIVmac251, a virus that has been reported to be partially suppressed by particular rhesus macaque TRIM5 variants.
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