AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis
X Gao, A Bashirova, AKN Iversen, J Phair, JJ Goedert… - Nature medicine, 2005 - nature.com
X Gao, A Bashirova, AKN Iversen, J Phair, JJ Goedert, S Buchbinder, K Hoots, D Vlahov…
Nature medicine, 2005•nature.comAn effective acquired immune response to infectious agents mediated by HLA-restricted T-
cell recognition can target different stages of disease pathogenesis. We show here that three
distinct HLA alleles known to alter the overall rate of AIDS progression act during distinct
intervals after HIV-1 infection. The discrete timing of HLA allele influence suggests
alternative functional mechanisms in immune defense against this dynamic and chronic
immunosuppressive disease.
cell recognition can target different stages of disease pathogenesis. We show here that three
distinct HLA alleles known to alter the overall rate of AIDS progression act during distinct
intervals after HIV-1 infection. The discrete timing of HLA allele influence suggests
alternative functional mechanisms in immune defense against this dynamic and chronic
immunosuppressive disease.
Abstract
An effective acquired immune response to infectious agents mediated by HLA-restricted T-cell recognition can target different stages of disease pathogenesis. We show here that three distinct HLA alleles known to alter the overall rate of AIDS progression act during distinct intervals after HIV-1 infection. The discrete timing of HLA allele influence suggests alternative functional mechanisms in immune defense against this dynamic and chronic immunosuppressive disease.
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