Clonal analysis suggests provirus expression in a subpopulation of human malignant trophoblast cells harbouring the human T cell lymphotropic virus type-I genome
Previous studies have indicated that the villous trophoblast may be involved in intrauterine
HTLV-I infection. Although the data furnished by our group (Liu et al., 1995) have
demonstrated that the human trophoblast-derived malignant cell lines JAR and JEG-3 are
susceptible to HTLV-I, the infection, even after thorough analysis, appeared to be limited to
expression at the transcriptional level. In the present report, we sought to explore virus
expression at the single cell level using eight clonally selected cell lines which were derived …
HTLV-I infection. Although the data furnished by our group (Liu et al., 1995) have
demonstrated that the human trophoblast-derived malignant cell lines JAR and JEG-3 are
susceptible to HTLV-I, the infection, even after thorough analysis, appeared to be limited to
expression at the transcriptional level. In the present report, we sought to explore virus
expression at the single cell level using eight clonally selected cell lines which were derived …