Increased glucose and placental GLUT-1 in large infants of obese nondiabetic mothers
O Acosta, VI Ramirez, S Lager, F Gaccioli… - American journal of …, 2015 - Elsevier
Objective Obese women are at increased risk to deliver a large infant, however, the
underlying mechanisms are poorly understood. Fetal glucose availability is critically
dependent on placental transfer and is linked to fetal growth by regulating the release of
fetal growth hormones such as insulin. We hypothesized that (1) umbilical vein glucose and
insulin levels and (2) placental glucose transporter (GLUT) expression and activity are
positively correlated with early pregnancy maternal body mass index and infant birthweight …
underlying mechanisms are poorly understood. Fetal glucose availability is critically
dependent on placental transfer and is linked to fetal growth by regulating the release of
fetal growth hormones such as insulin. We hypothesized that (1) umbilical vein glucose and
insulin levels and (2) placental glucose transporter (GLUT) expression and activity are
positively correlated with early pregnancy maternal body mass index and infant birthweight …