An animal model of adult T-cell leukemia: humanized mice with HTLV-1–specific immunity
K Tezuka, R Xun, M Tei, T Ueno… - Blood, The Journal …, 2014 - ashpublications.org
K Tezuka, R Xun, M Tei, T Ueno, M Tanaka, N Takenouchi, J Fujisawa
Blood, The Journal of the American Society of Hematology, 2014•ashpublications.orgKey Points Humanized mice, IBMI-huNOG, were generated by intra–bone marrow injection
of human CD133+ hematopoietic stem cells. HTLV-1–infected IBMI-huNOG mice
recapitulated distinct ATL-like symptoms as well as HTLV-1–specific adaptive immune
responses.
of human CD133+ hematopoietic stem cells. HTLV-1–infected IBMI-huNOG mice
recapitulated distinct ATL-like symptoms as well as HTLV-1–specific adaptive immune
responses.
Key Points
- Humanized mice, IBMI-huNOG, were generated by intra–bone marrow injection of human CD133+ hematopoietic stem cells.
- HTLV-1–infected IBMI-huNOG mice recapitulated distinct ATL-like symptoms as well as HTLV-1–specific adaptive immune responses.
ashpublications.org