COVID-19 patients display distinct SARS-CoV-2 specific T-cell responses according to disease severity

M Kroemer, L Spehner, L Vettoretti, A Bouard… - Journal of Infection, 2021 - Elsevier
Adaptive Immune responses generated by SARS-CoV-2 virus in convalescent patients
according to disease severity remain poorly characterized. To this end, we designed a
prospective study (NCT04365322) that included 60 COVID-19 convalescent patients (1-
month post infection) in two cohorts respectively entitled mild illness and severe pneumonia.
The monitoring of peripheral immune responses was performed using IFNᵧ ELISpot assay.
The serology index of each patient was investigated at the same time. Patients with severe …