[HTML][HTML] Role of the intracellular domain of the human type I interferon receptor 2 chain (IFNAR2c) in interferon signaling: Expression of IFNAR2c truncation mutants in …
D Russell-Harde, TC Wagner, MRS Rani… - Journal of Biological …, 2000 - ASBMB
A human cell line (U5A) lacking the type I interferon (IFN) receptor chain 2 (IFNAR2c) was
used to determine the role of the IFNAR2c cytoplasmic domain in regulating IFN-dependent
STAT activation, interferon-stimulated gene factor 3 (ISGF3) and c-sis-inducible factor (SIF)
complex formation, gene expression, and antiproliferative effects. A panel of U5A cells
expressing truncation mutants of IFNAR2c on their cell surface were generated for study.
Janus kinase (JAK) activation was detected in all mutant cell lines; however, STAT1 and …
used to determine the role of the IFNAR2c cytoplasmic domain in regulating IFN-dependent
STAT activation, interferon-stimulated gene factor 3 (ISGF3) and c-sis-inducible factor (SIF)
complex formation, gene expression, and antiproliferative effects. A panel of U5A cells
expressing truncation mutants of IFNAR2c on their cell surface were generated for study.
Janus kinase (JAK) activation was detected in all mutant cell lines; however, STAT1 and …