[HTML][HTML] A hot spot on interferon α/β receptor subunit 1 (IFNAR1) underpins its interaction with interferon-β and dictates signaling
NA de Weerd, AY Matthews, PR Pattie… - Journal of Biological …, 2017 - ASBMB
The interaction of IFN-β with its receptor IFNAR1 (interferon α/β receptor subunit 1) is vital for
host-protective anti-viral and anti-proliferative responses, but signaling via this interaction
can be detrimental if dysregulated. Whereas it is established that IFNAR1 is an essential
component of the IFNAR signaling complex, the key residues underpinning the IFN-β-
IFNAR1 interaction are unknown. Guided by the crystal structure of the IFN-β-IFNAR1
complex, we used truncation variants and site-directed mutagenesis to investigate domains …
host-protective anti-viral and anti-proliferative responses, but signaling via this interaction
can be detrimental if dysregulated. Whereas it is established that IFNAR1 is an essential
component of the IFNAR signaling complex, the key residues underpinning the IFN-β-
IFNAR1 interaction are unknown. Guided by the crystal structure of the IFN-β-IFNAR1
complex, we used truncation variants and site-directed mutagenesis to investigate domains …