[HTML][HTML] Unique pharmacological property of ISRIB in inhibition of Aβ-induced neuronal cell death
T Hosoi, M Kakimoto, K Tanaka, J Nomura… - Journal of …, 2016 - Elsevier
T Hosoi, M Kakimoto, K Tanaka, J Nomura, K Ozawa
Journal of Pharmacological Sciences, 2016•ElsevierA pharmacological approach to ameliorate Alzheimer's disease (AD) has not yet been
established. In the present study, we investigated the pharmacological characteristics of the
recently identified memory-enhancing compound, ISRIB for the amelioration of AD. ISRIB
potently attenuated amyloid β-induced neuronal cell death at concentrations of 12.5–25 nM,
but did not inhibit amyloid β production in the HEK293T cell line expressing the amyloid
precursor protein (APP). These results suggest that ISRIB possesses the unique …
established. In the present study, we investigated the pharmacological characteristics of the
recently identified memory-enhancing compound, ISRIB for the amelioration of AD. ISRIB
potently attenuated amyloid β-induced neuronal cell death at concentrations of 12.5–25 nM,
but did not inhibit amyloid β production in the HEK293T cell line expressing the amyloid
precursor protein (APP). These results suggest that ISRIB possesses the unique …
Abstract
A pharmacological approach to ameliorate Alzheimer's disease (AD) has not yet been established. In the present study, we investigated the pharmacological characteristics of the recently identified memory-enhancing compound, ISRIB for the amelioration of AD. ISRIB potently attenuated amyloid β-induced neuronal cell death at concentrations of 12.5–25 nM, but did not inhibit amyloid β production in the HEK293T cell line expressing the amyloid precursor protein (APP). These results suggest that ISRIB possesses the unique pharmacological property of attenuating amyloid β-induced neuronal cell death without affecting amyloid β production.
Elsevier