[HTML][HTML] C2-domains, structure and function of a universal Ca2+-binding domain
J Rizo, TC Sudhof - Journal of Biological Chemistry, 1998 - ASBMB
A vast amount of protein sequence data accumulated over recent years has revealed that
protein modules are widespread in nature. Many intracellular and extracellular proteins
consist, in part or fully, of combinations of protein modules. C2-domains, together with SH2,
PTB, PH, SH3, WW, and PDZ domains, are typical examples of intracellular protein modules.
These modules form independently folding domains of 80–160 residues with characteristic
binding properties; C2-domains bind Ca2+ and phospholipids, SH2 and PTB domains …
protein modules are widespread in nature. Many intracellular and extracellular proteins
consist, in part or fully, of combinations of protein modules. C2-domains, together with SH2,
PTB, PH, SH3, WW, and PDZ domains, are typical examples of intracellular protein modules.
These modules form independently folding domains of 80–160 residues with characteristic
binding properties; C2-domains bind Ca2+ and phospholipids, SH2 and PTB domains …