[HTML][HTML] Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer's disease related cognitive functioning
There is an urgent need to develop molecular biomarkers of brain age in order to advance
our understanding of age related neurodegeneration. Recently, we developed a highly
accurate epigenetic biomarker of tissue age (known as epigenetic clock) which is based on
DNA methylation levels. Here we use n= 700 dorsolateral prefrontal cortex (DLPFC)
samples from Caucasian subjects of the Religious Order Study and the Rush Memory and
Aging Project to examine the association between epigenetic age and Alzheimer's disease …
our understanding of age related neurodegeneration. Recently, we developed a highly
accurate epigenetic biomarker of tissue age (known as epigenetic clock) which is based on
DNA methylation levels. Here we use n= 700 dorsolateral prefrontal cortex (DLPFC)
samples from Caucasian subjects of the Religious Order Study and the Rush Memory and
Aging Project to examine the association between epigenetic age and Alzheimer's disease …
Abstract
There is an urgent need to develop molecular biomarkers of brain age in order to advance our understanding of age related neurodegeneration. Recently, we developed a highly accurate epigenetic biomarker of tissue age (known as epigenetic clock) which is based on DNA methylation levels. Here we use n= 700 dorsolateral prefrontal cortex (DLPFC) samples from Caucasian subjects of the Religious Order Study and the Rush Memory and Aging Project to examine the association between epigenetic age and Alzheimer’s disease (AD) related cognitive decline, and AD related neuropathological markers.
ncbi.nlm.nih.gov
