Myeloid-derived suppressor cells: critical cells driving immune suppression in the tumor microenvironment
KH Parker, DW Beury, S Ostrand-Rosenberg - Advances in cancer …, 2015 - Elsevier
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature
myeloid cells that suppress innate and adaptive immunity. MDSCs are present in many
disease settings; however, in cancer, they are a major obstacle for both natural antitumor
immunity and immunotherapy. Tumor and host cells in the tumor microenvironment (TME)
produce a myriad of pro-inflammatory mediators that activate MDSCs and drive their
accumulation and suppressive activity. MDSCs utilize a variety of mechanisms to suppress T …
myeloid cells that suppress innate and adaptive immunity. MDSCs are present in many
disease settings; however, in cancer, they are a major obstacle for both natural antitumor
immunity and immunotherapy. Tumor and host cells in the tumor microenvironment (TME)
produce a myriad of pro-inflammatory mediators that activate MDSCs and drive their
accumulation and suppressive activity. MDSCs utilize a variety of mechanisms to suppress T …
