Accumulation of long-chain fatty acids in the heart has been proposed to play a role in the
development of heart failure and diabetic cardiomyopathy. Several animal models with
increased cardiomyocyte lipid accumulation suggest a link between the accumulation of
lipid, cardiomyocyte cell death and the development of cardiomyopathy. In this review, we
discuss the mechanism through which fatty acid accumulation may contribute to the
development or progression of heart failure by initiation of apoptotic cell death. Long-chain …