The distribution and density of airway vasoactive intestinal polypeptide (VIP) binding sites in cystic fibrosis and asthma
RK Sharma, BJ Addis, PK Jeffery - Pulmonary Pharmacology, 1995 - Elsevier
The densities of airway binding sites for Vasoactive intestinal polypeptide (VIP) were
determined using 125I-labelled VIP (IVIP) and the technique of autoradiography applied to
cryostat sections. Tissue studied included: grossly normal airway tissue taken from lungs
resected for bronchial carcinoma (Ca; n= 11) and lungs removed at transplant from patients
with cystic fibrosis (CF; n= 7). Lung tissue obtained at post-mortem in cases of fatal asthma
(n= 3) or lobes resected for bronchiectasis (n= 3) were taken as further disease controls. In …
determined using 125I-labelled VIP (IVIP) and the technique of autoradiography applied to
cryostat sections. Tissue studied included: grossly normal airway tissue taken from lungs
resected for bronchial carcinoma (Ca; n= 11) and lungs removed at transplant from patients
with cystic fibrosis (CF; n= 7). Lung tissue obtained at post-mortem in cases of fatal asthma
(n= 3) or lobes resected for bronchiectasis (n= 3) were taken as further disease controls. In …