Commentary 10.1172/JCI130008
Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
Address correspondence to: Casey M. Theriot, Department of Population Health and Pathobiology, College of Veterinary Medicine, Research Building 406, North Carolina State University, 1060 William Moore Drive, Raleigh, North Carolina 27607, USA. Phone: 919.513.0711; Email: cmtherio@ncsu.edu.
Find articles by Theriot, C. in: JCI | PubMed | Google Scholar
Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
Address correspondence to: Casey M. Theriot, Department of Population Health and Pathobiology, College of Veterinary Medicine, Research Building 406, North Carolina State University, 1060 William Moore Drive, Raleigh, North Carolina 27607, USA. Phone: 919.513.0711; Email: cmtherio@ncsu.edu.
Find articles by Fletcher, J. in: JCI | PubMed | Google Scholar
First published August 12, 2019 - More info
Clostridioides difficile is a significant public health threat, and diagnosis of this infection is challenging due to a lack of sensitivity in current diagnostic testing. In this issue of the JCI, Robinson et al. use a logistic regression model based on the fecal metabolome that is able to distinguish between patients with non–C. difficile diarrhea and C. difficile infection, and to some degree, patients who are asymptomatically colonized with C. difficile. The authors construct a metabolic definition of human C. difficile infection, which could improve diagnostic accuracy and aid in the development of targeted therapeutics against this pathogen.
A subscription is required for you to read this article in full. If you are a subscriber, you may sign in to continue reading.
Click here to sign into your account.
Please select one of the subscription options, which includes a low-cost option just for this article.
If you are at an institution or library and believe you should have access, please check with your librarian or administrator (more information).
Please try these troubleshooting tips.